Resultado da pesquisa (3)

Termo utilizado na pesquisa hepatite infecciosa canina

#1 - Epidemiological, clinical and pathological aspects of infectious canine hepatitis: 15 cases, 38(8):1608-1614

Abstract in English:

ABSTRACT.- Souto E.P.F., Maia L.A., Ferreira J.S., Gomes L.C.V.M., Carneiro R.S., Driemeier D., Souza A.P. & Dantas A.F.M. 2018. [Epidemiological, clinical and pathological aspects of infectious canine hepatitis: 15 cases] Aspectos epidemiológicos, clínicos e anatomopatológicos da hepatite infecciosa canina: 15 casos. Pesquisa Veterinária Brasileira 38(8):1608-1614. Laboratório de Patologia Animal, Hospital Veterinário, Centro de Saúde e Tecnologia Rural, Universidade Federal de Campina Grande, Campus de Patos, Av. Universitária s/n, Bairro Santa Cecília, Patos, PB 58708-110, Brazil. E-mail: dantas.af@pq.cnpq.br We described the main epidemiological, clinical and pathological aspects of canine infectious hepatitis diagnosed in the Laboratory of Animal Pathology of the Federal University of Campina Grande during the period from January 2003 to December 2016. Of the 1,640 necropsied dogs, 15 were diagnosed as infectious canine hepatitis (0.91%). Of the dogs affected nine were males and six females. The ages ranged from 45 days to seven years, being most of them young. Ten animals were mixed breed, four were Poodles and one Rottweiler. Most of the dogs do not received any vaccine protocol. The dogs came from the municipalities of Patos, São Mamede and Teixeira, from Paraiba, northeastern of Brazil. Most of the dogs presented clinical course varying from hyperacute to acute. The main clinical signs were seizure, apathy and hyporexia. At necropsy, the major alterations were observed in the liver, which was pale to orange and with irregular reddish areas on the capsular surface, besides accentuation of the lobular pattern and edema in the wall of the gallbladder. Hemorrhages were observed in several organs. In the histopathology there was centrolobular necrosis of hepatocytes associated with intranuclear viral inclusion bodies, hemorrhages and mixed inflammatory infiltrate. The diagnosis was established based on the characteristic histopathological lesions and was confirmed by immunohistochemistry. Infectious canine hepatitis occurs occasionally in the Paraiba, affecting particularly young and unvaccinated dogs.

Abstract in Portuguese:

RESUMO.- Souto E.P.F., Maia L.A., Ferreira J.S., Gomes L.C.V.M., Carneiro R.S., Driemeier D., Souza A.P. & Dantas A.F.M. 2018. [Epidemiological, clinical and pathological aspects of infectious canine hepatitis: 15 cases] Aspectos epidemiológicos, clínicos e anatomopatológicos da hepatite infecciosa canina: 15 casos. Pesquisa Veterinária Brasileira 38(8):1608-1614. Laboratório de Patologia Animal, Hospital Veterinário, Centro de Saúde e Tecnologia Rural, Universidade Federal de Campina Grande, Campus de Patos, Av. Universitária s/n, Bairro Santa Cecília, Patos, PB 58708-110, Brazil. E-mail: dantas.af@pq.cnpq.br Descrevem-se os principais aspectos epidemiológicos, clínicos e anatomopatológicos de casos de hepatite infecciosa canina diagnosticados no Laboratório de Patologia Animal da Universidade Federal de Campina Grande, durante o período de janeiro de 2003 a dezembro de 2016. Dos 1.640 cães necropsiados, 15 foram diagnosticados como hepatite infecciosa canina (0,91%). Dos cães acometidos nove eram machos e seis fêmeas. As idades variaram de 45 dias a sete anos, sendo a maioria filhotes. Dez animais não apresentavam raça definida, quatro eram Poodles e um Rottweiler. A maioria dos cães não recebeu nenhum tipo de protocolo vacinal. Os cães eram oriundos dos municípios de Patos, São Mamede e Teixeira, pertencentes ao estado da Paraíba, Nordeste do Brasil. A maioria dos cães apresentou curso clínico variando de hiperagudo a agudo. Os principais sinais clínicos foram convulsão, apatia e hiporexia. Na necropsia, as principais alterações foram observadas no fígado que se apresentava de pálido a alaranjado e com áreas irregulares avermelhadas na superfície capsular, além de acentuação do padrão lobular e edema na parede da vesícula biliar. Hemorragias foram observadas em vários órgãos. Na histopatologia havia necrose centrolobular de hepatócitos associada a corpúsculos de inclusão viral intranucleares, hemorragia e infiltrado inflamatório misto. O diagnóstico foi estabelecido com base nas características lesões histopatológicas e foi confirmado por imuno-histoquímica. A hepatite infecciosa canina ocorre ocasionalmente na Paraíba, acometendo particularmente cães jovens e não vacinados.


#2 - Infectious canine hepatitis in naturally infected dogs: Pathological findings and immunohistochemical diagnosis, 31(2):158-164

Abstract in English:

ABSTRACT.- Oliveira E.C., Almeida P.R., Sonne L., Pavarini S.P., Watanabe T.T.N. & Driemeier D. 2011. [Infectious canine hepatitis in naturally infected dogs: Pathological findings and immunohistochemical diagnosis.] Hepatite infecciosa canina em cães naturalmente infectados: achados patológicos e diagnóstico imuno-histoquímico. Pesquisa Veterinária Brasileira 31(2):158-164. Setor de Patologia Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves 9090, Porto Alegre, RS 91540-000, Brazil. E-mail: davetpat@ufrgs.br Twenty-three dogs with infectious canine hepatitis (ICH) were analyzed, based on general data, clinicopathological findings, and immunohistochemistry. The main gross lesions were hepatic paleness (17/23), hepatomegaly (10/23), and hemorrhage (21/23). Gallbladder edema (11/23), fibrinous material on the hepatic capsular surface (8/23), and jaundice (6/23) were also found. Severe hepatic necrosis was observed in association with amphophilic or basophilic intranuclear inclusions inside hepatocytes and endothelial cells (22/23). Splenic and nodal lymphoid necrosis and hemorrhage associated with small number of intranuclear inclusions inside reticuloendothelial cells were identified. Immunohistochemistry (IHC) was positive for adenovirus type 1 in all animals, with the best staining pattern occurring in the liver (23/23), brain (22/22), cerebellum (16/20), and kidney (16/21). Greater amount of viral antigen was identified in hepatocytes and vascular endothelial cells from the brain and glomerular tuft.

Abstract in Portuguese:

RESUMO.- Oliveira E.C., Almeida P.R., Sonne L., Pavarini S.P., Watanabe T.T.N. & Driemeier D. 2011. [Infectious canine hepatitis in naturally infected dogs: Pathological findings and immunohistochemical diagnosis.] Hepatite infecciosa canina em cães naturalmente infectados: achados patológicos e diagnóstico imuno-histoquímico. Pesquisa Veterinária Brasileira 31(2):158-164. Setor de Patologia Veterinária, Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves 9090, Porto Alegre, RS 91540-000, Brazil. E-mail: davetpat@ufrgs.br Vinte e três cães com hepatite infecciosa canina (HIC) foram analisados com base nos seus dados gerais, achados clínicos, patológicos e imuno-histoquímicos. As principais lesões macroscópicas encontradas foram palidez do fígado (17/23), hepatomegalia (10/23) e hemorragia (21/23). Observou-se também edema da parede da vesícula biliar (11/23), malhas de fibrina cobrindo a superfície capsular hepática (8/23) e icterícia (6/23). Acentuada necrose hepatocelular foi encontrada associada à identificação de corpúsculos intranucleares anfofílicos e basofílicos em hepatócitos e células endoteliais (22/23) característicos de adenovírus. Identificou-se no baço e linfonodos necrose linfoide, hemorragia e menor ocorrência de corpúsculos intranucleares em células reticuloendoteliais. A imuno-histoquímica (IHQ) foi positiva para adenovírus canino tipo 1 em todos os animais analisados. Os principais órgãos positivos na IHQ foram fígado (23/23), telencéfalo (22/22), cerebelo (16/20) e rim (16/21). Maior marcação de antígenos viral foi observada em hepatócitos e no endotélio vascular do encefalo e dos tufos glomerulares renais.


#3 - Hepatite infecciosa canina: 62 casos, p.325-332

Abstract in English:

ABSTRACT.- Inkelmann M.A., Rozza D.B., Fighera R.A., Kommers G.D., Graça D.L., Irigoyen L.F. & Barros C.S.L. 2007. [Infectious canine hepatitis: 62 cases.] Hepatite infecciosa canina: 62 casos. Pesquisa Veterinária Brasileira 27(8):325-332. Departamento de Patologia, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil. E-mail: claudioslbarros@uol.com.br Necropsy reports from 5,361 dogs necropsied over a 43-year period (1964-2006) were reviewed in search for cases of infectious canine hepatitis (ICH). Sixty two (1.2%) cases of the disease were found. Most of the 62 affected dogs (91.9%,) were 2-year-old or less. Clinical signs were recorded in the necropsy files of 45 ICH affected dogs and included anorexia (55.6%), apathy (35.6%), diarrhea (35.6%) (often with blood [43,8%]), neurological signs (33.3%), vomiting (26.7%), petechiae and echymosis in the mucous membranes and/or skin (24.4%), hypothermia (20.0%), abdominal pain (15.6%), icterus (13.3%), enlargement and congestion of the tonsils (11.1%), fever (11.1%) and ascites (6.7%). The clinical courses lasted from few hours to 15 days. The most frequent necropsy findings included hepatic changes (87.1%), edematous, congested and hemorrhagic lymph nodes (51.6%), bloodstained fluid, clear fluid or whole blood in the abdominal cavity (35.5%), and petechial or paint-brush hemorrhages over the pleural (27.4%) and gastrointestinal (24.2%) serosal surfaces. In 12.9% of the cases there was a granularity to the intestinal serosa. Hemorrhages in the leptomeninges and in the substance of the brain were observed in 9.7% of the cases. Hepatic gross changes included moderately enlarged and more friable livers with marked lobular pattern, congestion and multifocal pale or hemorrhagic foci of necrosis. Films and strands of fibrin covered the hepatic surface in 20.4% of the cases and in 27.8% of the cases the gall bladder was thickened by edema. Zonal or randomly distributed multifocal hepatic necrosis (93.5%) associated with intranuclear inclusion bodies were the most consistent microscopic findings. Intranuclear inclusion bodies were found in the liver in every case and their detection was the criterium for confirmation of the diagnosis. The most significant microscopic extra-hepatic lesions included hemorrhages and intranuclear inclusion bodies in endothelial and reticuloendothelial cells of the renal glomeruli (50.0%) lymph nodes (47.8%), brain (27.8%), tonsils (25.0%) and spleen (10.0%).

Abstract in Portuguese:

ABSTRACT.- Inkelmann M.A., Rozza D.B., Fighera R.A., Kommers G.D., Graça D.L., Irigoyen L.F. & Barros C.S.L. 2007. [Infectious canine hepatitis: 62 cases.] Hepatite infecciosa canina: 62 casos. Pesquisa Veterinária Brasileira 27(8):325-332. Departamento de Patologia, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil. E-mail: claudioslbarros@uol.com.br Necropsy reports from 5,361 dogs necropsied over a 43-year period (1964-2006) were reviewed in search for cases of infectious canine hepatitis (ICH). Sixty two (1.2%) cases of the disease were found. Most of the 62 affected dogs (91.9%,) were 2-year-old or less. Clinical signs were recorded in the necropsy files of 45 ICH affected dogs and included anorexia (55.6%), apathy (35.6%), diarrhea (35.6%) (often with blood [43,8%]), neurological signs (33.3%), vomiting (26.7%), petechiae and echymosis in the mucous membranes and/or skin (24.4%), hypothermia (20.0%), abdominal pain (15.6%), icterus (13.3%), enlargement and congestion of the tonsils (11.1%), fever (11.1%) and ascites (6.7%). The clinical courses lasted from few hours to 15 days. The most frequent necropsy findings included hepatic changes (87.1%), edematous, congested and hemorrhagic lymph nodes (51.6%), bloodstained fluid, clear fluid or whole blood in the abdominal cavity (35.5%), and petechial or paint-brush hemorrhages over the pleural (27.4%) and gastrointestinal (24.2%) serosal surfaces. In 12.9% of the cases there was a granularity to the intestinal serosa. Hemorrhages in the leptomeninges and in the substance of the brain were observed in 9.7% of the cases. Hepatic gross changes included moderately enlarged and more friable livers with marked lobular pattern, congestion and multifocal pale or hemorrhagic foci of necrosis. Films and strands of fibrin covered the hepatic surface in 20.4% of the cases and in 27.8% of the cases the gall bladder was thickened by edema. Zonal or randomly distributed multifocal hepatic necrosis (93.5%) associated with intranuclear inclusion bodies were the most consistent microscopic findings. Intranuclear inclusion bodies were found in the liver in every case and their detection was the criterium for confirmation of the diagnosis. The most significant microscopic extra-hepatic lesions included hemorrhages and intranuclear inclusion bodies in endothelial and reticuloendothelial cells of the renal glomeruli (50.0%) lymph nodes (47.8%), brain (27.8%), tonsils (25.0%) and spleen (10.0%).


Colégio Brasileiro de Patologia Animal SciELO Brasil CAPES CNPQ UNB UFRRJ CFMV